#195 [Genome Construction]Manager or Scientist in Bioinformatics

Company Overview

As a biotechnology company, they develop and provide a unique large-scale genome construction platform.

While traditional genome editing involves “partially rewriting” specific genes, their platform is characterized by the ability to “design and reconstruct” extremely wide genome regions with high precision on a megabase (one million base pairs) scale. This allows them to grant cells and microorganisms sophisticated new functions that were previously impossible.

[Main Business Areas and Use Cases]

• Regenerative Medicine and Cell Therapy: They design and modify iPS cell genomes on a large scale to develop “Master Cell Lines” with controlled rejection, providing a foundation for next-generation cell therapeutics and safer, high-performance transplant medicine.

• Bio-manufacturing (Synthetic Biology): They provide solutions to optimize industrial microorganisms (bacteria, yeast, etc.) to produce pharmaceutical raw materials, sustainable biofuels, and high-function materials cleanly and efficiently.

[Strengths and Outlook]

• Global Technological Superiority: They possess world-class scientific expertise, including being the only Japanese participant in the International Yeast Genome Project “Sc2.0” and a key member of the international genome writing consortium “GP-write.”

• Universal OS for Cells: They aim to become a “universal operating system (OS)” for cell engineering.

• Rapid Growth: In July 2025, they raised 2.8 billion yen in Series A funding. They have also initiated joint research with leading US biotech companies and universities, accelerating their global expansion.

• Their headquarters are located in San Carlos, California (Silicon Valley), and they are accelerating their U.S. operations. Even while based in Japan, you can always work directly connected to the U.S. ecosystem and market.

Job Description

They create various large-scale genome-modified cells in collaborative research with major partner companies and in their own research. Next-generation sequencing (NGS) analysis is a crucial technology for verifying the accuracy of genome editing techniques and analyzing cell phenotypes. You will be responsible for bioinformatics work, primarily focusing on the various NGS analyses performed by their company.

■Expected Job Responsibilities

・Quality control of genome-edited cells using whole genome sequencing analysis (analysis of fastq.gz read data)

・RNA-seq analysis/pathway analysis/scRNA-seq analysis/ATAC-seq analysis/Perturb-seq analysis targeting human cells

・Optimization of genome design using machine learning, deep learning, and large-scale language models

・Construction and fine-tuning of transformer-based bio-based models

・Utilization and operation of AWS cloud servers

・Utilization of lab automation (automated cell culture equipment)

Requirements

・Hands-on experience using AI/AI-agentic tools for coding and software development.
・Proven experience in managing human-centric bioinformatics research projects, from experimental design to final analysis.
・Deep expertise in analyzing human biological data, particularly with Whole Genome Sequencing (WGS) and RNA-seq datasets.
・High proficiency in a command-line environment (e.g., Linux, Bash).
・Programming Expertise:
・Mandatory: Advanced programming skills in Python or R.
・Welcomed: Experience with Shell Scripting, C++, Rust, JavaScript/TypeScript, or SQL (MySQL/PostgreSQL).

Preferred Requirements

・Experience in data manipulation and bioinformatics analysis on AWS.
・Practical experience as a system/infrastructure engineer (maintenance of AWS cloud servers or on-premise servers, etc.).
・Experience in machine learning, deep learning, LLM development, or MLOps.
・TOEIC score of 700 or higher.
・A minimum of 3 years of relevant work experience.

Terms and Conditions

• Annual Salary: 5 – 9 million JPY (negotiable)

• Bonus: None

• Salary Increase: Once a year

• Probation Period: 6 months

• Location: Kanagawa

• Social Insurance: Fully covered

• Working Hours: Based on 9:00-18:00 (left to the individual’s discretion)

• Holidays: Saturdays, Sundays, and National Holidays

• Average Overtime: Discretionary labor system

• Smoking Cessation Measures: Non-smoking indoors

Selection Process

• Selection Flow: They conduct 2–3 interviews followed by a reference check.

• Required Documents: They require a resume and a curriculum vitae (CV) for the initial screening.

• Interview Language: Their interviews can be conducted in either Japanese or English.